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InsuJet Insulin Therapy: Benefits, Dosing, Features, and more (2023)

Written by: Content Team



Time to read 8 min

Many people with diabetes rely on insulin therapy to control their condition. The traditional methods of insulin administration are through an insulin syringe and needle, whether using insulin vials or a conventional insulin pen.

There are many drawbacks to these modes of insulin delivery that range from issues with absorption to unpleasant side effects. A needle-free jet injection system, like InsuJet, can mitigate these problems and offer a better, more consistent way of controlling blood glucose levels.

So here's all you need to know about InsuJet insulin therapy: the device's features, benefits, and dosing modes and how it differs from conventional needle injections.

What Is the InsuJet Needle-Free Insulin Injection System?

InsuJet is a portable medical device that looks like a regular insulin pen, but instead of a needle injection, it has a needle-free nozzle for subcutaneous insulin administration.

The mode of action for needle-free jet injection is simple. Insulin is loaded into InsuJet through an insulin vial adapter. The device has a spring-loaded mechanism, so once loaded   it's placed at 90 degrees against the injection site where it releases the prescribed dose through a fine jet stream into the subcutaneous tissue.

The device is designed with comfort in mind, allowing for comfortable needle-free insulin delivery and ideal insulin absorption.

Benefits of the InsuJet Needle-Free Jet Injector

Jet injection during insulin therapy has many benefits that InsuJet consistently delivers for patients, which include:

Ideal Therapy for Patients with Needle Phobia

Needle phobia is the fear of receiving treatment via needle injections. According to a 2019 systematic review and meta-analysis of 119 research papers, prevalence estimates for needle fear ranged from 20-50% in adolescents and 20-30% in young adults.

For people with insulin-dependent diabetes, this could be detrimental to their adherence to insulin therapy, which usually requires multiple daily injections.

Feedback for InsuJet devices indicates that 91% of customers have some degree of needle phobia. The needle-free injection device helps lower their anxiety about managing their condition.

Improved Early Postprandial Glucose Control

Subcutaneous insulin administration closely mimics the natural pancreatic response to food by releasing insulin. The biggest hurdle in current therapy attempts is the delayed action of rapid-acting insulin analogs.

That leads to high blood sugar after meals, called postprandial hyperglycemia.

An InsuJet jet injector allows the insulin to spread over a large area of the subcutaneous fat layer beneath the skin. This makes the onset of drug action faster and more predictable, which helps with its blood glucose-lowering effect and prevents fluctuations.

You can read more about it in this study published by Diabetes Care journal, "Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology."

The jet injection also improves the pharmacodynamics of regular human insulin, allowing it to perform similarly to insulin as part and other rapid-acting insulin analogs injected subcutaneously using a conventional pen.

In clinical studies performed on healthy volunteers, jet-injected human insulin outperformed traditionally injected insulin as part of its onset of action.

Lower Obesity-Dependent Insulin Absorption Variability

Insulin injection using a syringe into midsection
Insulin injection. Source: Deposit Photos

For overweight or obese patients, a common issue is the variability in insulin absorption using a conventional pen or syringe.

InsuJet virtually eliminates this variability, allowing consistent insulin delivery for patients with a higher body mass index (BMI). That's because the mechanism of action allows the insulin to spread across a wider area instead of penetrating deeper into the fat layer under the skin.

Lower Risk of Needlestick Injuries and Cross-Contamination

Needlestick injuries during insulin injection can be a common occurrence in healthcare settings. Using an insulin syringe or a conventional pen needle for insulin administration increases the risk of needlestick injury for the patient, caregivers, and healthcare providers.

InsuJet prevents these incidents as it doesn't contain a sharp needle. It also makes the disposal of consumables less hassle, as the spent adaptor and nozzle can be discarded with regular household waste.

Lower Risk of Intramuscular Injections

Intramuscular insulin injection risks unpredictable absorption due to the nature of muscle fibres. This reduces the insulin's blood glucose-lowering effect.

Unfortunately, for underweight patients, an incorrect injection technique with conventional pen needles or insulin syringes can increase the risk of injecting insulin into a muscle.

Jet injection allows patients of all sizes to have a reliable, consistent experience without the influence of external factors.

Safer for the Environment

Discarded needle
Discarded needle. Source:

Using traditional insulin syringes or insulin pens with needles produces a lot of plastic waste. Considering the life-long nature of insulin therapy, this translates into a large environmental footprint for each patient.

Innovative devices like InsuJet can be used for up to 5,000 injections. They also reduce waste thanks to reusable nozzle technology. A single nozzle lasts for two weeks or 56 injections, whichever comes first.

Aside from changing the nozzle, if the InsuJet device hasn't been used for three consecutive days, you can significantly reduce medical waste by switching to InsuJet.

Lower Monthly Cost

The upfront high cost of buying a new InsuJet needle-free insulin injection system could deter some patients from opting for it.

The monthly maintenance costs of using needles or a conventional pen may be more cost-effective. Market studies also show that the breakeven point of savings using InsuJet devices happens around 11 months. 

So, considering the 5,000-injection lifespan of the InsuJet, which could easily last for three years, it remains a cost effective alternative to conventional insulin syringes with needles and insulin pens.

InsuJet Needle-Free Jet Injector Dosing

<a href=InsuJet insulin injector kit being filled" data-srcset=" 1800w, 1600w, 1400w, 1200w, 1000w, 800w, 600w, 400w">
InsuJet insulin injector kit being filled

Here are a few important pointers when it comes to using the InsuJet jet injector dosing:

  • InsuJet is a mode of administration, not an alternative therapy option.
  • Using an InsuJet device for injecting insulin shouldn't affect the insulin dose your physician prescribes you.
  • You should only use U-100 insulin with the InsuJet.
  • You can administer 4 to 50 units of insulin per shot.
  • To mitigate the side effects of large insulin doses, such as bleeding and bruising, you can split the dose into two injections.

Features of the InsuJet Needle-Free Jet Injector

The InsuJet needle-free solution has some important features that make subcutaneous injections less intimidating for patients with insulin-dependent diabetes. 

These features come together to form a meticulously engineered device that helps patients administer insulin painlessly and with ease, like:

Reusable Nozzle

InsuJet Kit Nozzle
InsuJet Kit Nozzle

Insulin is dispensed through a reusable, replaceable nozzle with a tiny hole for the needle-free jet injection.

The nozzle can be used for up to two weeks or 56 subcutaneous injections, so you don't have to worry about changing it too often.

It's also a much more eco-conscious option since the consumable lasts longer than traditional needles or disposable insulin pens.

Comfort Ring

InsuJet Kit Ring
InsuJet Kit Ring

A comfort ring can be fitted on the nozzle to soften the pressure of the injection in sensitive injection sites. This feature ensures that the needle-free injection doesn't affect soft areas prone to bruising.

Nozzle Lock

The nozzle lock secures the nozzle in place before the device can inject insulin into your bloodstream. This prevents the nozzle from dislodging and insulin leaking, tampering with your dose, and increasing the risk of not controlling blood sugar levels properly.

Easy Dosage Adjustment

Adjusting the dose of insulin administered couldn't be easier with the InsuJet device. All you have to do is twist the top part until the number indicator shows you the correct number of units. You can administer a minimum of 4 and 50 units of the drug in a single injection.

Safety Lock

The safety mechanism prevents undesired shots from firing when you don't intend to inject insulin. After you slide the red lock and hold it there, the mechanism unlocks. That way, you can safely press the device against the intended area to administer insulin.

Two Insulin Vial Adaptor Sizes

Hands holding InsuJet nozzles
Hands holding InsuJet nozzles

Since an insulin prescription can come in either 3 ml or 10 ml vials, the InsuJet needle-free device can work with either size when fitted with the correct adaptor.

Side Effects of Using the InsuJet Needle-Free Jet Injector

You might experience one or more of these side effects while using the InsuJet needle-free device:

Common Side Effects

Uncomfortable Administration

Just like with conventional insulin syringes and needle injections, using InsuJet might cause some discomfort if the injection is close to a nerve ending. Storing your insulin in the refrigerator can also contribute to painful injections.


A tiny droplet of blood at the site of the InsuJet nozzle's small orifice is common. Use a sterile cotton swab to wipe the blood after injecting insulin. If the bleeding persists beyond that, seek medical attention immediately.


Woman with needle bruises
Woman with needle bruises. Source: Deposit Photos

If you're prone to bruising using conventional injection methods, you might face some bruising while using InsuJet. Use the Comfort Ring to lower the injection pressure at sensitive areas.

Raised White Bump

When insulin is injected shallowly, right under the skin instead of in the subcutaneous fat layer, a raised white bump where the insulin accumulates might appear. If your insulin dose is high, consider splitting it into two smaller injections to prevent this from happening.

Scar Tissue/Skin Hardening

The body responds to tissue injury, like an injection, by forming scar tissue that's harder and more resilient than regular skin. To avoid the formation of scar tissue, rotate the insulin injection site frequently.

Uncommon Side Effects

Intramuscular (IM) Injection

Injecting insulin into a site without much fat can lead to intramuscular insulin injection. Avoid that, as IM injection causes insulin absorption variability, which might lead to hyperglycemia.

Rare Side Effects


At the beginning of insulin therapy, some individuals might notice itchiness, redness, and swelling at the injection site. If these symptoms don't naturally subside, seek medical attention.

Very Rare Side Effects


Although sporadic, bacterial contamination of the injection site can sometimes cause infection.

Ensuring the injection site is clean before injection, replacing consumables on time, and not using a malfunctioning needle-free jet injector can protect you from infection.

The InsuJet Starter Pack

To get started, you can opt for the InsuJet Starter Pack, which contains the following:

  • InsuJet Needle-Free Jet Injector: Compatible with all U-100 insulin types.
  • 5pc Nozzle + Comfort Ring: For precise, comfortable injection.
  • A 10 mm Adaptor: For 10 ml insulin vials.
  • A 3 mm Adaptor: For 3 ml insulin cartridges and disposable insulin pen cartridges.

Available in 40 countries with plans to expand to other markets soon, InsuJet is the optimal solution for pain-free, needle-free insulin injections.

To Wrap Up

Opting for InsuJet to administer insulin is a giant leap in your insulin therapy journey's safety, consistency, and overall quality. 

Aside from the stellar engineering, the InsuJet device also values comfort and ease of operation, giving you the treatment option you deserve.

Try the superior experience of using the InsuJet needle-free jet injection system now!

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